From his Quora post:
The job as CEO of reddit is incredibly stressful and draining. After two and a half years, I'm basically completely worn out, and it was having significantly detrimental effects on my personal life. If anything, I probably pushed myself way too far - as a first-time CEO, all I knew was that such jobs are supposed to be stressful, so I never really had a good baseline, i.e. how stressful is too stressful, until multiple outside people and coaches I was working with remarked to me that I looked incredibly worn down for months on end and it wasn't supposed to be this hard.
Entrepreneurship is hard. Starting and building a company is hard -- even with established companies such as Reddit. Which is why first time founders should ask themselves: "Am I ready for the challenge?", then, be prepared to be honest with yourselves, to know when to ask for help.
From a VC standpoint, an investor's job isn't just providing money to get entrepreneur's visions started. Investors are also there to help coach and mentor.
Having a solid support network can make a world of difference. Things to in mind as you begin your entrepreneurial journey.